Recentes publicações citando produtos StemCell

 M3134

Harder KW, Quilici C, Naik E, Inglese M, Kountouri N, Turner A, Zlatic K, Tarlinton DM, Hibbs ML: Perturbed myelo/erythropoiesis in Lyn-deficient mice is similar to that in mice lacking the inhibitory phosphatases SHP-1 and SHIP-1. Blood 104(13): 3901-3910, 2004

Qian H, Tryggvason K, Jacobsen SE, Ekblom M:  Contribution of alpha6 integrins to hematopoietic stem and progenitor cell homing to bone marrow and collaboration with alpha4 integrins.  Blood. 107(9): 3503-10, 2006

Chan IT, Kutok JL, Williams IR, Cohen S, Moore S, Shigematsu H, Ley TJ, Akashi K, Le Beau MM, Gilliland DG:  Oncogenic K-ras cooperates with PML-RAR alpha to induce an acute promyelocytic leukemia-like disease.  Blood. 108(5): 1708-15, 2006

Cheung YY, Kim SY, Yiu WH, Pan CJ, Jun HS, Ruef RA, Lee EJ, Westphal H, Mansfield BC, Chou JY:  Impaired neutrophil activity and increased susceptibility to bacterial infection in mice lacking glucose-6-phosphatase-beta. J Clin Invest. 117(3): 784-793, 2007

Eguchi M, Eguchi-Ishimae M, Green A, Enver T, Greaves M: Directing oncogenic fusion genes into stem cells via an SCl enhancer. Proc Nat Acad Sci 102(4), 1133-1138, 2005

Heinonen KM, Dube N, Bourdeau A, Lapp WS, Tremblay ML:  Protein tyrosine phosphatase 1B negatively regulates macrophage development through CSF-1 signaling.  Proc Natl Acad Sci U S A. 103(8): 2776-81, 2006

Heinzel K, Benz C, Martins VC, Haidl ID, Bleul CC:  Bone marrow-derived hemopoietic precursors commit to the T cell lineage only after arrival in the thymic microenvironment.  J Immunol. 178(2): 858-68, 2007

Khaldoyanidi S, Sikora L, Broide D, Rothenberg M, Sriramoarao P: Constitutive overexpression of IL-5 induces extramedullary hematopoiesis in the spleen.  Blood 101: 863-868, 2003

Matsumura-Takeda K, Sogo S, Isakari Y, Harada Y, Nishioka K, Kawakami T, Ono T, Taki T:  CD41+/CD45+ cells without acetylcholinesterase activity are immature and a major megakaryocytic population in murine bone marrow.  Stem Cells. 2007  (Epub ahead of print)

Moriguchi T, Hamada M, Morito N, Terunuma T, Hasegawa K, Zhang C, Yokomizo T, Esaki R, Kuroda E, Yoh K, Kudo T, Nagata M, Greaves DR, Engel JD, Yamamoto M, Takahashi S:  MafB is essential for renal development and F4/80 expression in macrophages.  Mol Cell Biol.  26(15): 5715-27, 2006

Mukai HY, Motohashi H, Ohneda O, Suzuki N, Nagano M, Yamamoto M:  Transgene Insertion into the Proximity of the c-myb gene Disrupts Erythroid-Megakaryocytic Lineage Bifurcation.  Mol Cell Biol. 2006 (Epub ahead of print)

Nakorn T, Miyamoto T, Weissman IL: Characterization of mouse clonogenic megakaryocyte progenitors.  Proc Natl Acad Sci USA 100: 205-210, 2003

Van Meter ME, Diaz-Flores E, Archard JA, Passegue E, Irish JM, Kotecha N, Nolan GP, Shannon K, Braun BS:  K-RasG12D expression induces hyperproliferation and aberrant signaling in primary hematopoietic stem/progenitor cells.  Blood. 2006 (Epub ahead of print)

Xing S, Ho WT, Zhao W, Ma J, Wang S, Xu X, Li Q, Fu X, Xu M, Zhao ZJ: Transgenic expression of JAK2V617F causes myeloproliferative disorders in mice. Blood. 2008 (Epub ahead of print)

M3234
Braun BS, Archard JA, Van Ziffle JAG, Tuveson DA, Jacks TE, Shannon K: Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo. Blood 108(6) 2041-2044, 2006

Cain JA, Xiang Z, O'neal J, Kreisel F, Colson A, Luo H, Hennighausen L, Tomasson MH:  Myeloproliferative disease induced by TEL-PDGFRB displays dynamic range sensitivity to Stat5a gene dosage. Blood. 2007 (Epub ahead of print)

Heuser M, Argiropoulos B, Kuchenbauer F, Yung E, Piper J, Fung S, Schlenk RF, Dohner K, Hinrichsen T, Rudolph C, Schambach A, Baum C, Schlegelberger B, Dohner H, Ganser A, Humphries RK: MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in AML patients. Blood. 2007 (Epub ahead of print)

Kumagai T, O'Kelly J, Said JW, Koeffler HP: Vitamin D2 analog 19-nor-1,25-dihydroxyvitamin D2: Antitumor activity against leukemia, myeloma, and colon cancer cells.  J Natl Cancer Inst 95: 896-905, 2003

Lacout C, Pisani DF, Tulliez M, Gachelin FM, Vainchenker W, Villeval JL:  JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis.  Blood. 108(5): 1652-60, 2006

Pandit TS, Sikora L, Muralidhar G, Rao SP, Sriramarao P:  Sustained exposure to nicotine leads to extramedullary hematopoiesis in the spleen.  Stem Cells. 24(11): 2373-81, 2006

Qyang Y, Chambers SM, Wang P, Xia X, Chen X, Goodell MA, Zheng H: Myeloproliferative disease in mice with reduced presenilin gene dosage: effect of γ-secretase blockage. Biochem 43: 5352-5359, 2004

Sjogren AK, Andersson KM, Liu M, Cutts BA, Karlsson C, Wahlstrom AM, Dalin M, Weinbaum C, Casey PJ, Tarkowski A, Swolin B, Young SG, Bergo MO: GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer. J Clin Invest. 117(5):1294-1304, 2007

Sun W, Downing JR: Haploinsufficiency of AML1 results in a decrease in the number of LTR-HSCs while simultaneously inducing an increase in more mature progenitors. Blood 104: 3565-3572, 2004

Wahlstrom AM, Cutts BA, Karlsson C, Andersson KM, Liu M, Sjogren AK, Swolin B, Young SG, Bergo MO:  Rce1 deficiency accelerates the development of a K-RAS-induced myeloproliferative disease.  Blood.  109(2): 763-768, 2007

Wernig G, Mercher T, Okabe R, Levine RL, Lee BH, Gilliland DG:  Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model.  Blood. 107(11): 4274-81, 2006

Wiedmer T, Zhao J, Li L, Zhou Q, Hevener A, Olefsky JM, Curtiss LK, Sims PJ: Adiposity, dyslipidemia, and insulin resistance in mice with targeted deletion of phospholipid scramblase 3 ( PLSCR3). Proc Nat Aca Sci 101(36): 13296-13301, 2004

Yoon D, Pastore YD, Divoky V, Liu E, Mlodnicka AE, Rainey K, Ponka P, Semenza GL, Schumacher A, Prchal JT:  Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development. J Biol Chem. 281(35): 25703-11, 2006

M3236
Griswold IJ, MacPartlin M, Bumm T, Goss VL, O'Hare T, Lee KA, Corbin AS, Stoffregen EP, Smith C, Johnson K, Moseson EM, Wood LJ, Polakiewicz RD, Druker BJ, Deininger MW:  Kinase domain mutants of Bcr-Abl exhibit altered transformation potency, kinase activity, and substrate utilization, irrespective of sensitivity to imatinib.  Mol Cell Biol. 26(16): 6082-93, 2006

Yoon D, Pastore YD, Divoky V, Liu E, Mlodnicka AE, Rainey K, Ponka P, Semenza GL, Schumacher A, Prchal JT:  Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development. J Biol Chem. 281(35): 25703-11, 2006

M3334

Dumitriu B, Patrick MR, Petschek JP, Cherukuri S, Klingmuller U, Fox PL, Lefebvre V:  Sox6 cell-autonomously stimulates erythroid cell survival, proliferation, and terminal maturation and is thereby an important enhancer of definitive erythropoiesis during mouse development.  Blood. 108(4): 1198-207, 2006

Gruber M, Hu CJ, Johnson RS, Brown EJ, Keith B, Simon MC:  Acute postnatal ablation of Hif-2{alpha} results in anemia.  PNAS.  104(7): 2301-6, 2007

Heavey B, Charalambous C, Cobaleda C, Busslinger M: Myeloid lineage switch of Pax5 mutant but not wild-type B cell progenitors by C/EBP and GATA factors.  EMBO J 22: 3887-3897, 2003

Heo K, Jariwala U, Woo J, Zhan Y, Burke KA, Zhu L, Anderson WF, Zhao Y:  Involvement of Niemann-Pick type C2 protein in hematopoiesis regulation.  Stem Cells.  24(6): 1549-55, 2006

McDevitt MA, Xie J, Shanmugasundaram G, Griffith J, Liu A, McDonald C, Thuma P, Gordeuk VR, Metz
CN, Mitchell R, Keefer J, David J, Leng L, Bucala R:  A critical role for the host mediator macrophage migration inhibitory factor in the pathogenesis of malarial anemia. J Exp Med.  203(5): 1185-96, 2006

Perry JM, Harandi OF, Paulson RF:  BMP4, SCF and hypoxia cooperatively regulate the expansion of murine stress erythroid progenitors.  Blood. 2007 (Epub ahead of print)

Pilon AM, Arcasoy MO, Dressman HK, Vayda SE, Maksimova YD, Sangerman JI, Gallagher PG, Bodine DM: Failure of terminal erythroid differentiation in EKLF-deficient mice is associated with cell cycle perturbation and reduced expression of E2F2. Mol Cell Biol 28: 7394-7401, 2008

Yoshida T, Yao-Ming NS, Suniga-Pflucker JC, Georgopoulos K: Early hematopoietic lineage restrictions directed by Ikaros.  Nature Immunology 7(4): 382-391, 2006

M3430
Yoon D, Pastore YD, Divoky V, Liu E, Mlodnicka AE, Rainey K, Ponka P, Semenza GL, Schumacher A, Prchal JT:  Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development. J Biol Chem. 281(35): 25703-11, 2006

M3434
Alberta J, Springett G, Rayburn H, Natoli T, Loring J, Kreidberg J, Housman D: Role of the WT1 tumor suppressor in murine hematopoiesis.  Blood 101: 2570-2574, 2003

Anderson K, Rusterholz C, Mansson R, Jensen CT, Bacos K, Zandi S, Sasaki Y, Nerlov C, Sigvardsson M, Jacobsen SE:  Ectopic expression of PAX5 promotes self renewal of bi-phenotypic myeloid progenitors co-expressing myeloid and B-cell lineage associated genes.  Blood. 2007  (Epub ahead of print)

Baba Y, Yokota T, Spits H, Garrett KP, Hayashi S, Kincade PW:  Constitutively active beta-catenin promotes expansion of multipotent hematopoietic progenitors in culture.  J Immunol. 177(4): 2294-303, 2006

Ball CR, Pilz IH, Schmidt M, Fessler S, Williams DA, von Kalle C, Glimm H: Stable differentiation and clonality of murine long-term hematopoiesis after extended reduced-intensity selection for MGMT P140K transgene expression. Blood. 110(6): 1779-1787, 2007

Biffi A, Capotondo A, Fasano S, Del Carro U, Marchesini S, Azuma H, Malaguti MC, Amadio S, Brambilla R, Grompe M, Bordignon C, Quattrini A, Naldini L:  Gene therapy of metachromatic leukodystrophy reverses neurological damage and deficits in mice.  J Clin Invest. 116(11): 3070-3082, 2006

Bourdeau A, Dube N, Heinonen KM, Theberge JF, Doody KM, Tremblay ML:  TC-PTP-deficient bone marrow stromal cells fail to support normal B lymphopoiesis due to abnormal secretion of interferon-{gamma}  Blood. 2007 (Epub ahead of print)

Cain JA, Xiang Z, O'neal J, Kreisel F, Colson A, Luo H, Hennighausen L, Tomasson MH:  Myeloproliferative disease induced by TEL-PDGFRB displays dynamic range sensitivity to Stat5a gene dosage. Blood. 2007 (Epub ahead of print)

Camargo FD, Chambers SM, Drew E, McNagny KM, Goodell MA:  Hematopoietic stem cells do not engraft with absolute efficiencies.  Blood. 107(2): 501-7, 2006

Cammenga J, Niebuhr B, Horn S, Bergholz U, Putz G, Buchholz F, Lohler J, Stocking C:  RUNX1 DNA-Binding Mutants, Associated with Minimally Differentiated Acute Myelogenous Leukemia, Disrupt Myeloid Differentiation.  Cancer Res. 67(2): 537-45, 2007

Carella C, Potter M, Bonten J, Rehg JE, Neale G, Grosveld GC:  The ETS factor TEL2 is a hematopoietic oncoprotein. Blood. 107(3): 1124-32, 2006

Chan IT, Kutok JL, Williams IR, Cohen S, Moore S, Shigematsu H, Ley TJ, Akashi K, Le Beau MM, Gilliland DG:  Oncogenic K-ras cooperates with PML-RAR alpha to induce an acute promyelocytic leukemia-like disease.  Blood. 108(5) 1708-15, 2006

Chen Y, Haviernik P, Bunting KD, Yang Y: Cited2 is required for normal hematopoiesis in the murine fetal liver. Blood. 2007 (Epub ahead of print)

Cianfarani F, Zambruno G, Brogelli L, Sera F, Lacal PM, Pesce M, Capogrossi MC, Failla CM, Napolitano M, Odorisio T: Placenta Growth Factor in Diabetic Wound Healing. Am J Pathol. 169(4): 1167-1182, 2006

Coletta PL, M�ller AM, Jones EA, M�hl B, Holwell S, Clarke D, Meade JL, Cook GP, Hawcroft G, Ponchel F, Lam WK, MacLennan KA, Hull MA, Bonifer C, Markham AF: Lyphodepletion in the ApcMin/+ mouse model of intestinal tumorigenesis.  Blood 103: 1050-1058, 2004

Dahl R, Iyer SR, Owens KS, Cuylear DD, Simon MC:  The Transcriptional Repressor GFI-1 Antagonizes PU.1 Activity through Protein-Protein Interaction.  J Biol Chem. 282(9): 6473-83, 2007

De Palma M, Montini E, Santoni de Sio FR, Benedicenti F, Gentile A, Medico E, Naldini L: Promoter trapping reveals significant differences in integration site selection between MLV and HIV vectors in primary hematopoietic cells. Blood 105(6): 2307-2315, 2005

Deonarain R, Verma A, Porter A, Gewert D, Platanias L, and Fish E: Critical roles for IFN in lymphoid development, myelopoiesis, and tumor development: Links to tumor necrosis factor . Proc Natl Acad Sci USA 100: 13453-13458, 2003

Dimascio L, Voermans C, Uqoezwa M, Duncan A, Lu D, Wu J, Sankar U, Reya T:  Identification of adiponectin as a novel hemopoietic stem cell growth factor.  J Immunol. 178(6): 3511-20, 2007

Dorrance AM, Liu S, Yuan W, Becknell B, Arnoczky KJ, Guimond M, Strout MP, Feng L, Nakamura T, Yu L, Rush LJ, Weinstein M, Leone G, Wu L, Ferketich A, Whitman SP, Marcucci G, Caligiuri MA:   Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations.  J Clin Invest. 116(10): 2707-16, 2006

Doyonnas R, LaBarge MA, Sacco A, Charlton C, Blau HM: Hematopoietic contribution to skeletal muscle regeneration by myelomonocytic precursors. Proc Natl Acad Sci USA 101(37): 13507-13512, 2004

Eckardt S, Leu NA, Bradley HL, Kato H, Bunting KD, McLaughlin KJ:  Hematopoietic reconstitution with androgenetic and gynogenetic stem cells.  Genes Dev. 21(4): 409-19, 2007

Feral CC, Rose DM, Han J, Fox N, Silverman GJ, Kaushansky K, Ginsberg MH: Blocking the alpha 4 integrin-paxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site.  J Clin Invest. 116(3): 715-23, 2006

Finstad SL, Rosenberg N, Levy LS: Diminished Potential for B-Lymphoid Differentiation after Murine Leukemia Virus Infection In Vivo and in EML Hematopoietic Progenitor Cells. J Virol. 2007 (Epub ahead of print)

Goyama S, Yamaguchi Y, Imai Y, Kawazu M, Nakagawa M, Asai T, Kumano K, Mitani K, Ogawa S, Chiba S, Kurokawa M, Hirai H: The transcriptionally active form of AML1 is required for hemapoietic rescue of the AML1-deficient embryonic para-aortic splanchnopleural (P-Sp) region. Blood 104(12): 3558-3564, 2004

Gruber M, Hu CJ, Johnson RS, Brown EJ, Keith B, Simon MC:  Acute postnatal ablation of Hif-2{alpha} results in anemia.  PNAS.  104(7): 2301-6, 2007

Gu TL, Mercher T, Tyner JW, Goss VL, Walters DK, Cornejo MG, Reeves C, Popova L, Lee K, Rush J, Daibata M, Miyoshi I, Gilliland DG, Druker BJ, Polakiewicz RD:  A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia.  Blood. 2007  (Epub ahead of print)

Gurevich RM, Aplan PD, Humphries RK: NUP98-Topoisomerase I acute myeloid leukemia-associated fusion gene has potent leukemogenic activities independent of an engineered catalytic site mutation.  Blood 104(4): 1127-1136, 2004

Han XD, Lin C, Chang J, Sadelain M, Kan YW: Fetal gene therapy of {alpha}-thalassemia in a mouse model. Proc Natl Acad Sci U S A. 2007 (Epub ahead of print)

Heavey B, Charalambous C, Cobaleda C, Busslinger M: Myeloid lineage switch of Pax5 mutant but not wild-type B cell progenitors by C/EBP and GATA factors.  EMBO J 22: 3887-3897, 2003

Heinonen KM, Dube N, Bourdeau A, Lapp WS, Tremblay ML:  Protein tyrosine phosphatase 1B negatively regulates macrophage development through CSF-1 signaling.  Proc Natl Acad Sci U S A. 103(8): 2776-81, 2006

Horton SJ, Walf-Vorderwulbecke V, Chatters SJ, Sebire NJ, de Boer J, Williams O: Acute myeloid leukemia induced by MLL-ENL is cured by oncogene ablation despite acquisition of complex genetic abnormalities. Blood 2008 (Epub ahead of print)

Hu YL, Passegue E, Fong S, Largman C, Lawrence HJ:  Evidence that the Pim1 kinase gene is a direct target of HOXA9 and a mediator of HOXA9's effects on hematopoiesis.  Blood. 2007  (Epub ahead of print)

Ito CY, Li C, Bernstein A, Dick J, Stanford W: Hematopoietic stem cell and progenitor defects in Sca-1/Ly-6A-null mice.  Blood 101: 517-523, 2003

Jiang X, Stuible M, Chalandon Y, Li A, Chan W, Eisterer W, Krystal G, Eaves A, Eaves C: Evidence for a positive role of SHIP in the BCR-ABL-mediated transformation of primitive murine hematopoeitic cells and in human chronic myeloid leukemia.  Blood 102: 2976-2984, 2003

Kim A, Morgan K, Hasz DE, Wiesner SM, Lauchle JO, Geurts JL, Diers MD, Le DT, Kogan SC, Parada LF, Shannon K, Largaespada DA:  {beta} common receptor inactivation attenuates myeloproliferative disease in Nf1 mutant mice.  Blood. 109(4): 1687-91, 2007

Kimura Y, Jones N, Kl�ppel M, Hirashima M, Tachibana K, Cohn JB, Wrana JL, Pawson T, Berstein A: Targeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineages. Proc Nat Aca Sci 101(16): 6015-6020, 2004

Kitsos CM, Sankar U, Illario M, Colomer-Font JM, Duncan AW, Ribar TJ, Reya T, Means AR: Calmodulin-dependent protein kinase IV regulates hematopoietic stem cell maintenance.  J Biol Chem 280(39), 33101-33108, 2005

Kriz V, Agren N, Lindholm CK, Lenell S, Saldeen J, Mares J, Welsh M:  The SHB adapter protein is required for normal maturation of mesoderm during in vitro differentiation of embryonic stem cells.  J Biol Chem.  281(45): 34484-91, 2006

Kuang S, Charge SB, Seale P, Huh M, Rudnicki MA:  Distinct roles for Pax7 and Pax3 in adult regenerative myogenesis.  J Cell Biol. 172(1): 103-13, 2006

Kurita R, Sasaki E, Yokoo T, Hiroyama T, Takasugi K, Imoto H, Izawa K, Dong Y, Hashiguchi T, Soda Y, Maeda T, Suehiro Y, Tanioka Y, Nakazaki Y, Tani K:  Tal1/Scl gene transduction using a lentiviral vector stimulates highly efficient hematopoietic cell differentiation from common marmoset (Callithrix jacchus) embryonic stem cells.  Stem Cells.  24(9): 2014-22, 2006

Kyba M, Perlingeiro RCR, Hoover RR, Lu C-W, Pierce J, Daley GQ: Enhanced hematopoietic differentiation of embryonic stem cells conditionally expressing Stat5.  Proc Natl Acad Sci USA 100: 11904-11910, 2003

Liang Y, Van Zant G, Szilvassy SJ: Effects of aging on the homing and engraftment of murine hematopoietic stem and progenitor cells. Blood 106(4): 1479-87, 2005

Lin H, Lei J, Wininger D, Nguyen M, Khanna R, Hartmann C, Yan W, Huang S: Multilineage potential of homozygous stem cells derived from metaphase II oocytes.  Stem Cells 21: 152-161, 2003

Ling K-W, Ottersbach K, van Hamburg JP, Oziemlak A, Tsai F-Y, Orkin SH, Ploemacher R, Hendriks RW, Dzierzak E: GATA-2 Plays Two Functionally Distinct Roles during the Ontogeny of Hematopoietic Stem Cells. J Exp Med 200(7), 871-882, 2004

Liu H, Roy K: Biomimetic three-dimensional cultures significantly increase hematopoietic differenation efficiacy of embryonic stem cells. Tiss Eng 11(1/2), 319-330, 2005

Ma Y, Cui W, Yang J, Qu J, Di C, Amin HM, Lai R, Ritz J, Krause DS, Chai L:  SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice.  Blood. 108(8): 2726-35, 2006

Maes C, Coenegrachts L, Stockmans I, Daci E, Luttun A, Petryk A, Gopalakrishnan R, Moermans K, Smets N, Verfaillie CM, Carmeliet P, Bouillon R, Carmeliet G:  Placental growth factor mediates mesenchymal cell development, cartilage turnover, and bone remodeling during fracture repair. J Clin Invest.  116(5): 1230-42, 2006

Mercher T, Wernig G, Moore SA, Levine RL, Gu TL, Frohling S, Cullen D, Polakiewicz RD, Bernard OA, Boggon TJ, Lee BH, Gilliland DG:  JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model.  Blood. 108(8): 2770-9, 2006

Miura Y, Gao Z, Miura M, Seo BM, Sonoyama W, Chen W, Gronthos S, Zhang L, Shi S:  Mesenchymal Stem Cell-Organized Bone Marrow Elements: An Alternative Hematopoietic Progenitor Resource.  Stem Cells. 2006  (Epub ahead of print)

Nakagawa M, Ichikawa M, Kumano K, Goyama S, Kawazu M, Asai T, Ogawa S, Kurokawa M, Chiba S:  AML1/Runx1 rescues Notch1-Null mutation-induced deficiency of para-aortic splanchnopleural hematopoiesis.  Blood. 2006 (Epub ahead of print)

Nottingham WT, Jarratt A, Burgess M, Speck CL, Cheng J, Prabhakar S, Rubin EM, Li P, Sloane-Stanley J, Kong-a-San J, de Bruijn MFTR: Runx1-mediated hematopoietic stem cell emergence is controlled by a Gata/Ets/Scl-regulated enhancer. Blood. 2007 (Epub ahead of print)

Okamoto R, Ueno M, Yamada Y, Takahashi N, Sano H, Suda T, Takakura N:  Hematopoietic cells regulate the angiogenic switch during tumorigenesis. Blood 105(7), 2757-2763, 2005

Pandit TS, Sikora L, Muralidhar G, Rao SP, Sriramarao P:  Sustained exposure to nicotine leads to extramedullary hematopoiesis in the spleen.  Stem Cells. 24(11): 2373-81, 2006

Perlingeiro R, Kyba M, Bodie S, Daley GQ: A role for thrombopoietin in hemangioblast development.  Stem Cells 21: 272-280, 2003

Pimanda JE, Chan WY, Wilson NK, Smith AM, Kinston S, Knezevic K, Janes ME, Landry JR, Kolb-Kokocinski A, Frampton J, Tannahill D, Ottersbach K, Follows GA, Lacaud G, Kouskoff V, G�ttgens B: Endoglin expression in blood and endothelium is differentially regulated by modular assembly of the Ets/Gata hemangioblast code. Blood 112: 4512-4522, 2008

Pineault N, Buske C, Feuring-Buske M, Abramovitch C, Rosten P, Hogge D, Aplan P, Humphries RK: Induction of acute myeloid leukemia in mice by the human leukemia-specific fusion gene NUP98-HOXD13 in concert with Meis1.  Blood 101: 4529-4538, 2003

Pineault N, Abramovich C, Ohta H, Humphries RK: Differential and common leukomogenic potentials of multiple NUP98-Hox fusion proteins along or with Meis1. Mol Cel Biol 24(5): 1907-1917, 2004

Priestley GV, Ulyanova T, Papayannopoulou T:  Sustained alterations in biodistribution of stem/progenitor cells in Tie2Cre+ alpha4(f/f) mice are hematopoietic cell autonomous. Blood. 109(1): 109-11, 2007

Puri M, Bernstein A: Requirement for the TIE family of receptor tyrosine kinases in adult but not fetal hematopoiesis.  Proc Natl Acad Sci USA 100: 12753-12758, 2003

Rawat V, Cusan M, Deshpande A, Hiddemann W, Quintanilla-Martinez L, Humphries R, Bohlander S, Feuring-Buske M, Buske C: Ectopic expression of the homeobox gene Cdx2 is the transforming event in a mouse model of t(12;13)(p13;q12) acute myeloid leukemia.  Proc Natl Acad Sci USA 101: 817-822, 2004

Rawat VP, Thoene S, Naidu VM, Arseni N, Heilmeier B, Metzeler K, Petropoulos K, Deshpande A, Quintanilla-Martinez L, Bohlander SK, Spiekermann K, Hiddemann W, Feuring-Buske M, Buske C: Overexpression of CDX2 perturbs HOX gene expression in murine progenitors depending on its N-terminal domain and is closely correlated with deregulated HOX gene expression in human acute myeloid leukemia. Blood. 2007 (Epub ahead of print)

Sakai R, Kajiume T, Inoue H, Kanno R, Miyazaki M, Ninomiya Y, Kanno M: TCDD treatment eliminates the long-term reconstitution activity of hematopoietic stem cells.  Toxicol Sci 72: 84-91, 2003

Sata M, Saiura A, Kunisato A, Tojo A, Okada S, Tokuhisa T, Hirai H, Makuuchi M, Hirata Y, Nagai R: Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of artherosclerosis.  Nat Med 8: 403-409, 2002

Spike BT, Dibling BC, Macleod KF: Hypoxic stress underlies defects in erythroblast islands in the Rb-null mouse. Blood. 110(6): 2173-2181, 2007

Sun W, Downing JR: Haploinsufficiency of AML1 results in a decrease in the number of LTR-HSCs while simultaneously inducing an increase in more mature progenitors. Blood 104: 3565-3572, 2004

Tan W, Huang W, Zhong Q, Schwarzenberger P:  IL-17 receptor knockout mice have enhanced myelotoxicity and impaired hemopoietic recovery following gamma irradiation.  J Immunol. 176(10): 6186-93, 2006

Tan B, Hong L, Munugalavadla V, Kapur R: Functional and biochemical consequences of abrogating the activation of multiple diverse early signaling pathways in Kit.  Role for Src kinase pathway in Kit-induced cooperation with erythropoietin receptor.  J Biol Chem 278: 11686-11695, 2003

Trowbridge JJ, Scott MP, Bhatia M: Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regeneration.  PNAS. 103(38): 14134-14139, 2006

Uhmann A, Dittmann K, Nitzki F, Dressel R, Koleva M, Frommhold A, Zibat A, Binder C, Adham I, Nitsche M, Heller T, Armstrong V, Schulz-Schaeffer W, Wienands J, Hahn H: The Hedgehog receptor Patched controls lymphoid lineage commitment. Blood. 110(5): 1814-1823, 2007

Van Meter ME, Diaz-Flores E, Archard JA, Passegue E, Irish JM, Kotecha N, Nolan GP, Shannon K, Braun BS:  K-RasG12D expression induces hyperproliferation and aberrant signaling in primary hematopoietic stem/progenitor cells.  Blood. 2006 (Epub ahead of print)

Visnjic D, Kalajzic Z, Rowe DW, Katavic V, Lorenzo J, Aguila HL: Hematopoiesis is severely altered in mice with an induced osteoblast deficiency.  Blood 103(9): 3258-3264, 2004  

Weisberg EL, Catley L, Wright RD, Moreno D, Banerji L, Ray A, Manley PW, Mestan J, Fabbro D, Jiang J, Hall-Meyers E, Callahan L, Dellagatta JL, Kung AL, Griffin JD:  Beneficial effects of combining nilotinib and imatinib in preclinical models of BCR/ABL+ leukemias. Blood. 2006 (Epub ahead of print)

Wernig G, Mercher T, Okabe R, Levine RL, Lee BH, Gilliland DG:  Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model.  Blood. 107(11): 4274-81, 2006

Wong JCY, Alon N, McKerlie C, Huang JR, Meyn MS, Buchwald M: Targeted disruption of exons 1 to 6 of the Fanconi anemia group A gene leads to growth retardation, strain-specific microphthalmia, meiotic defects and primordial germ cell hypoplasia.  Hum Mol Genet 12: 2063-2076, 2003

Wood N, Whitters M, Jacobson B, Witek J, Sypek J, Kasaian M, Eppihimer M, Unger M, Tanaka T, Goldman S, Collins M, Donaldson D, Grusby M: Enhanced Interleukin (IL)-13 responses in mice lacking IL-13 receptor 2.  J Exp Med 197: 703-709, 2003

Wulf G, Luo K, Goodell M, Brenner M: Anti-CD45-mediated cytoreduction to facilitate allogeneic stem cell transplantation.  Blood 101: 2434-2439, 2003

Yoshida T, Yao-Ming NS, Suniga-Pflucker JC, Georgopoulos K: Early hematopoietic lineage restrictions directed by Ikaros.  Nature Immunology 7(4): 382-391, 2006

Zhang CC, Steele AD, Lindquist S, Lodish HF: Prion protein is expressed on long-term repopulating hematopoietic stem cells and is important for their self-renewal.   Proc Natl Acad Sci U S A. 103(7): 2184-9, 2006

Zhang Z, Cotta CV, Stephan RP, de Guzman CG, Klug CA: Enforced expression of EBF in hematopoietic stem cells restricts lymphopoiesis to the B cell lineage.  EMBO J 22: 4759-4769, 2003

Zheng X, Beissert T, Kukoc-Zivojnov N, Puccetti E, Altschmied J, Strolz C, Boelurer S, Gul H, Schneider O, Ottmann OG, Hoelzer D, Henschler R, Ruthardt M: Gamma-catenin contributes to leukemogenesis induced by AML-associated translocation products by increasing the self-renewal of very primitive progenitor cells. Blood 103(9): 3535-3543, 2004

Xing S, Ho WT, Zhao W, Ma J, Wang S, Xu X, Li Q, Fu X, Xu M, Zhao ZJ: Transgenic expression of JAK2V617F causes myeloproliferative disorders in mice. Blood. 2008 (Epub ahead of print)

M3534
Chen W, Li Q, Hudson WA, Kumar A, Kirchhof N, Kersey JH:  A murine Mll-AF4 knock-in model results in lymphoid and myeloid deregulation and hematologic malignancy.  Blood. 108(2): 669-77, 2006

Chen YX, Yan J, Keeshan K, Tubbs AT, Wang H, Silva A, Brown EJ, Hess JL, Pear WS, Hua X:  The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression.  PNAS.  103(4): 1018-23, 2006

Johnson JJ, Chen W, Hudson W, Yao Q, Taylor M, Rabbitts TH, Kersey JH: Prenatal and postnatal myeloid cells demonstrate stepwise progression in the pathogenesis of MLL fusion gene leukemia.  Blood 101: 3229-3235, 2003

Kubota Y, Kinoshita K, Suetomi K, Fujimori A, Takahashi S:  Mcl-1 Depletion in Apoptosis Elicited by Ionizing Radiation in Peritoneal Resident Macrophages of C3H Mice. J Immunol. 178(5): 2923-31, 2007

Li H, Watford W, Li C, Parmelee A, Bryant MA, Deng C, O�shea J, Lee SB: Ewing sarcoma gene EWS is essential for meiosis and B lymphocyte development. J Clin Invest. 117(5): 1314-1323, 2007

Meng A, Wang Y, Van Zant G, Zhou D: Ionizing radiation and busulfan induce premature senescencein murine bone marrow hematopoietic cells.  Cancer Res 63: 5414-5419, 2003

Miyake N, Brun AC, Magnusson M, Miyake K, Scadden DT, Karlsson S:  HOXB4-induced self-renewal of hematopoietic stem cells is significantly enhanced by p21 deficiency.   Stem Cells. 24(3): 653-61, 2006

Nefedova Y, Huang M, Kusmartsev S, Bhattacharya R, Cheng P, Salup R, Jove R, Gabrilovich D: Hyperactivation of STAT3 Is Involved in Abnormal Differentiation of Dendritic Cells in Cancer.  J Immunol 172: 464-474, 2004

Wendel HG, de Stanchina E, Cepero E, Ray S, Emig M, Fridman JS, Veach DR, Bornmann WG, Clarkson B, McCombie WR, Kogan SC, Hochhaus A, Lowe SW:  Loss of p53 impedes the antileukemic response to BCR-ABL inhibition. PNAS. 103(19): 7444-9, 2006

M3630
Baens M, Fevery S, Sagaert X, Noels H, Hagens S, Broeckx V, Billiau AD, De Wolf-Peeters C, Marynen P:  Selective expansion of marginal zone B cells in Emicro-API2-MALT1 mice is linked to enhanced IkappaB kinase gamma polyubiquitination.  Cancer Res. 66(10): 5270-7, 2006

Bourdeau A, Dube N, Heinonen KM, Theberge JF, Doody KM, Tremblay ML:  TC-PTP-deficient bone marrow stromal cells fail to support normal B lymphopoiesis due to abnormal secretion of interferon-{gamma}  Blood. 2007 (Epub ahead of print)

Chen W, Li Q, Hudson WA, Kumar A, Kirchhof N, Kersey JH:  A murine Mll-AF4 knock-in model results in lymphoid and myeloid deregulation and hematologic malignancy.  Blood. 108(2): 669-77, 2006

Chou WC, Levy DE, Lee CK:  STAT3 positively regulates an early step in B-cell development. Blood. 108(9): 3005-11, 2006

Coletta PL, M�ller AM, Jones EA, M�hl B, Holwell S, Clarke D, Meade JL, Cook GP, Hawcroft G, Ponchel F, Lam WK, MacLennan KA, Hull MA, Bonifer C, Markham AF: Lyphodepletion in the ApcMin/+ mouse model of intestinal tumorigenesis.  Blood 103: 1050-1058, 2004

Finstad SL, Rosenberg N, Levy LS: Diminished Potential for B-Lymphoid Differentiation after Murine Leukemia Virus Infection In Vivo and in EML Hematopoietic Progenitor Cells. J Virol. 2007 (Epub ahead of print)

Kharas MG, Yusuf I, Scarfone VM, Yang VW, Segre JA, Huettner CS, Fruman DA: KLF4 suppresses transformation of pre-B cells ABL oncogenes. Blood. 2006 (Epub ahead of print)

Li H, Watford W, Li C, Parmelee A, Bryant MA, Deng C, O�shea J, Lee SB: Ewing sarcoma gene EWS is essential for meiosis and B lymphocyte development. J Clin Invest. 117(5): 1314-1323, 2007

Nemeth MJ, Kirby MR, Bodine DM: Hmgb3 regulates the balance between hematopoietic stem cell self-renewal and differentiation. Proc Natl Acad Sci USA 103(37): 13783-13788, 2006

Pineault N, Buske C, Feuring-Buske M, Abramovitch C, Rosten P, Hogge D, Aplan P, Humphries RK: Induction of acute myeloid leukemia in mice by the human leukemia-specific fusion gene NUP98-HOXD13 in concert with Meis1.  Blood 101: 4529-4538, 2003

Portis T, Longnecker R: Epstein-Barr virus LMP2A interferes with global transcription factor regulation when expressed during B-lymphocyte development.  J Virol 77: 105-114, 2003

Teglund S, McKay C, Schuetz E, van Deursen JM, Stravopodis D, Wang D, Brown M, Bodner S, Grosveld G, Ihle JN: Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses.  Cell 93: 841-850, 1998

Zhang CC, Steele AD, Lindquist S, Lodish HF: Prion protein is expressed on long-term repopulating hematopoietic stem cells and is important for their self-renewal.   Proc Natl Acad Sci U S A. 103(7): 2184-9, 2006

Other Applications
Eichler H, Kern S, Beck C, Zieger W, Kluter H: Engraftment capacity of umbilical cord blood cells processed by either whole blood preparation of filtration.  Stem Cells 21: 208-216, 2003

Iwasaki-Arai J, Iwasaki H, Miyamoto T, Watanabe S, Akashi K: Enforced granulocyte/macrophage colony-stimulating factor signals do not support lymphopoiesis, but instruct lymphoid to myelomonocytic lineage conversion.  J Exp Med 197: 1311-1322, 2003

Koptyra M, Falinski R, Nowicki MO, Stoklosa T, Majsterek I, Nieborowska-Skorska M, Blasiak J, Skorski T: BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance. Blood 108(1): 319-327, 2006

Mangla A, Khare A, Vineeth V, Panday NN, Mukhopadhyay A, Ravindran B, Bal V, George A, Rath S: Pleiotropic consequences of Bruton tyrosine kinase deficiency in myeloid lineages lead to poor inflammatory responses. Blood 104(4): 1191-1197, 2004

Ning S, Hartley C, Molineux G, Knox SJ: Darbepoietin Alfa Potentiates the Efficacy of Radiation Therapy in Mice with Corrected or Uncorrected Anemia. Cancer Res 65(1): 284-290, 2005

Zinkel S, Ong C, Ferguson D, Iwasaki H, Akashi K, Bronson R, Kutok J, Alt F, Korsmeyer SJ: Proapoptotic BID is required for myeloid homeostasis and tumor suppression.  Genes Dev 17: 229-239, 2003